The third one-day international at the Home of Cricket, will be both countries final matches before embarking on the ICC tournament.
England, already lead the series, due to a fantastic hundred by one-day captain, Eoin Morgan, at Headingley. The Irishman will be playing on his home ground, where he bats for Middlesex.
South Africa, who have a fantastic record in the Capital, having won test matches in 1994, 2003 and 2012, will be looking to boost their Champions Trophy record performances by winning in the final match of the series in the Capital.
Ticket prices start at £45 and £20 for Under-16, please check www.lords.org for more details.
If you already have tickets for the match, please take your time getting to the ground and getting in as there may be additional searches carried out, due to recent events in Manchester.