John Stamos has been tipped as the favourite to replace Charlie Sheen on Two and a Half Men, according to Paddy Power.

Sheen has amassed more than 2.4million Twitter followers and attracted over 74,000 applicants in his search for a social media intern to join Team Sheen, but the once highest paid actor in the US is jobless and the search is on to find a replacement for the former ‘Two and a Half Men’ star.

Paddy Power have made ‘Full House’ star John Stamos their 7/2 favourite to takeover from Sheen on the hugely popular CBS show. Rob Lowe is the second favourite at 4/1 although his contract with ‘Parks and Recreation’ would make a move to ‘Two and a Half Men’ very difficult.

Of course there is a chance ‘Two and a Half Men’ may never be back on the small screen. Paddy Power are quoting 4/7 that the show will be scrapped for good.  

Sharon McHugh, spokesperson for Paddy Power said: “By sacking Sheen CBS have proved that no man is invincible&hellipeven if they do claim to be a warlock!”  

Will Two and a Half Men be back with a new star?
4/7 No
5/4 Yes

Charlie Sheen’s replacement on Two and a Half Men
 7/2 John Stamos
 4/1 Rob Lowe
 5/1 Matt Dillon
12/1 Matt Le Blanc
16/1 Ricky Gervais
16/1 Seth Rogen
16/1 Jason Segel
20/1 Jon Hamm
20/1 Jason Sudeikis
20/1 Will Ferrell
20/1 Dane Cook
25/1 Sean Penn
25/1 Hugh Grant
25/1 Alec Baldwin
25/1 Steve Carell
33/1 Colin Farrell
33/1 Jude Law
33/1 Seann William Scott
33/1 Jerry Seinfeld
33/1 Chris Rock
40/1 Jason Priestly
40/1 Will Smith
40/1 Mel Gibson
40/1 Russell Brand
50/1 Emilio Estevez