The hip hop superstar, 42, will join Coldplay on stage, and has vowed to wow the worldwide audience of one billion.
The entertainers are expected to be joined by the popular Rihanna. The few remaining tickets to the event are expected to sell out fast with the news.
The closing ceremony has been named the ‘Festival Of Flame’ and will feature the themes of earth, wind, water, fire and ice.
Coldplay singer Chris Martin said: “Being asked to play at the closing celebrations for the Paralympic athletes in London is such a great honour for us.
“Kim Gavin and Misty Buckley are working hard to put on a spectacular Paralympic Games Closing Ceremony for the athletes and spectators in the stadium, and everyone watching around the world, and we are so happy to be involved.”
The Daily Mirror reported a show source as saying: “Jay-Z and Chris Martin are close friends so he helped to get the rapper on board.
“They are putting together a spectacular set list – one likely to include a duet.
“It’s going to be one hell of a show and fans of both artists will be clamouring for tickets.
“The Paralympics has exceeded all expectation and, like the rest of the world, Jay-Z has been blown away by their bravery and athleticism.
“This will be a concert like no other and a fantastic end to what has been the most successful Paralympics ever.”