Three days of heavy rainfall in the region caused riverbanks to burst and cut off roads.
At least 12 camps within the reserve could not be reached by road and 10 entrance gates were closed, officials reported.
A doctor who works at the main camp of Skukuza said that tourists and staff in the cut-off camps were safe, but stranded.
Helicopter evacuations began after a group of holidaymakers were isolated by flooding during a game drive.
Hm, don’t reckon it’d be much fun to be stranded in a reserve surrounded by lions, eh?
The reserve had been around 50 per cent occupied after the peak safari period over the Christmas holidays, it is reported.
The park is now said to be getting back to normal as the rainfall has stopped.