A total of 45 cases of the Buruli ulcer have been reported across Victoria this year.

There is no concrete evidence to suggest how the disease is spread, but water, mosquitoes and possums have all come under suspicion.

The disease eats at the skin and leads to gangrene if left untreated. It can result in amputation of the arms and legs.

Victoria is the only place outside of the tropics that Buruli has been reported.