Doctor Conrad Murray was on the phone for a 45 minutes while Michael Jackson died a court heard today.

The prosecution for Murray's involuntary manslaughter charge accused him of administering a 25mg dose of anesthetic Propofol to the singer at 10.40am on June 25, 2009, before making five phone calls, including one to cocktail waitress Sade Anding.

The prosecution argued that it was during this final phone call at 11.51 am that Murray realised Jackson was in trouble.

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"This phone call is likely the time Conrad Murray first noticed Michael Jackson's lifeless body," Deputy District Attorney David Walgren told the jury. "It won't reveal to you the time of Michael Jackson's death but it may reveal to you when Conrad Murray first noticed he had died.”

"Sade Anding was speaking on the phone when she realized there was no response on the other end.”

"Conrad Murray was not communicating, he was not responding to the conversation. She eventually hung up and tried to get back in touch with Conrad Murray but there was no response."

An ambulance was called at 12.20pm, but Jackson was pronounced dead at the scene six minutes later.

Murray, 58, who was reportedly getting paid $96,000 a month as Jackson’s private doctor is accused of killing Jackson with an overdose of Propofol, a powerful sedative. He could face four years in jail if found guilty.

The doctor's defence team argue Michael took the fatal does of the sedative himself.

Meanwhile protestors supporting and condemning Murray gathered outside the court as the trial continues.