The Scot, who admitted there were “butterflies there”, will play Belgium’s David Goffin, ranked 104th in the world, on Centre Court on Monday.
He told reporters he was looking to win the tournament.
“I’m here to try and win,” he said. “And that’s it.”
Murray ended Britain’s 77-year wait for a men’s singles champion at the All England Club last summer, beating Novak Djokovic.
“I’m going to be nervous,” Britain’s No.1 tennis player added. “I know there’s going to be pressure.”
Murray, whose new coach Amelie Mauresmo is herself a Wimbledon champion, is 7/2 to lift his second title at SW19 in two weeks’ time, with Djokovic the favorite at 7/4.
Rafa Nadal is 4/1 and Roger Federer 11/2.
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